Anti-Estrogen Drugs

Antiestrogenic drugs – the perfect solution during anabolic steroids cycles.

Of the antiestrogens used in clinical practice, Tamoxifen and Clomiphene Citrate deserve special attention. But you can also take a look at such high-quality pills as Anastrozole, Exemestane, Letrozole which are available for sale at our online pharmacy.

Tamoxifen Citrate, one of the most active antiestrogens, is used mainly as an antitumor agent for estrogen-dependent tumors (breast cancer in women, endometrial cancer), as well as for anovulatory infertility, while clomiphene citrate is used mainly for endocrine disorders of ovulation, breast cancer, as well as to stimulate the synthesis of gonadotropins in men.

Clomiphene Citrate is considered one of the main antiestrogenic drugs, and its chemical structure is close to chlorotrianisen (a synthetic drug with estrogenic activity) and tamoxifen (a drug with antiestrogenic activity).

How do Anti Estrogens work?

The mechanism of the antiestrogenic action of Clomiphene Citrate consists in competitive binding in the hypothalamus and in the ovary with estrogen receptors and thus preventing the formation of an estrogen-receptor complex with the endogenous agonist 17β-estradiol. As a result of blocking estrogen receptors with clomiphene citrate by a feedback mechanism (no effect of estrogens on the pituitary gland – a signal of estrogen deficiency), the secretion of gonadotropic hormones – prolactin, FSH and LH is stimulated and, as a consequence, ovarian function is stimulated and ovulation is induced. However, the stimulation of ovulation with clomiphene citrate is manifested only when it is used in small doses – in large doses, the drug can cause inhibition of the secretion of gonadotropins.

Clomiphene citrate is an antiestrogenic drug by the mechanism of action at the level of estrogen receptors, while in terms of the end effects it causes, it can be attributed to stimulators of gonadotropin secretion, ovarian function, and, therefore, to stimulators of estrogen synthesis. It was found that with an insufficient content of estrogens in the blood, clomiphene citrate increases the synthesis of estrogens, however, with a high level of estrogens in the blood, the synthesis of estrogens under the influence of the drug decreases. Clomiphene citrate has neither androgenic nor gestagenic activity.

When taken orally, clomiphene citrate is rapidly and completely absorbed into the bloodstream, metabolized in the liver, excreted in the bile, undergoing enterohepatic recirculation, and has a fairly long half-life (T1/2 – 5-7 days).

Indications for prescription and usage

At first – during cycles with anabolic steroids. Every professional bodybuilder knows that Anti Estrogens are MUST-HAVE drugs when using steroids. If we talk about the regular medical practice you can use it in the induction of ovulation in women with anovulatory cycle and associated infertility, dysfunctional menorrhagias, dysgonadotropic forms of amenorrhea, galactorrhea (with the exclusion of its tumor genesis), Stein-Leventhal sclerocystic ovary syndrome, as well as androgen deficiency and oligospermia in men. The drug can also be used to study the gonadotropic function of the pituitary gland.

Possible Side Effects

In case of overdose, you can face headache, nausea, vomiting, depression, irritability, insomnia, weight gain, vasomotor symptoms, hot flashes, diarrhea, transient visual impairment, more rarely hair loss, allergic dermatitis, breast pain, dysmenorrhea, polyuria, pollakiuria, thromboembolic complications. Taking clomiphene citrate, like other ovulation stimulants, increases the likelihood of multiple pregnancies.

When treating Clomiphene Citrate, special attention should be paid to the study of ovarian function – the drug can cause hyperstimulation and hypertrophy. Clinically, ovarian hyperstimulation and hypertrophy are manifested by an increase in their size, pain in the lower abdomen, flatulence, menorrhagia, an increase in the concentration of estrogen in the blood (the karyopycnotic index is more than 70-80% and the excretion of estrogen is above 200 μg / day).

In connection with the possibility of the development of the above side effects of clomiphene citrate, patients receiving this drug should be under medical supervision. In addition, it is necessary to find out the degree of its effectiveness with each course of treatment with clomiphene citrate. In particular, the onset of ovulation is confirmed in the presence of a biphasic basal body temperature, an average cyclical increase in the content of LH and progesterone in the blood. In cases where ovulation has occurred, but pregnancy has not occurred, it is necessary to repeat the course of treatment with clomiphene citrate (in the same doses as during the previous course). Care must be taken especially in cases where there is no menstrual bleeding after ovulation has taken place: it is possible that this is due to the onset of pregnancy. In any case, however, the decision to initiate a new course of treatment with clomiphene should be made only after a possible pregnancy has been ruled out.

If after three cycles of treatment with clomiphene citrate there is no therapeutic effect, further use of the drug (in the form of repeated three five-day cycles) is permissible after a three-month break, however, if there is no effect after that, then further use of the drug is useless.

Contradictions

If you decided to buy Anti-Estrogen pills you must know that these drugs are contraindicated in pregnancy, impaired liver and kidney function, uterine bleeding of unknown etiology, ovarian cyst, genital neoplasms.

How to find a trusted source with Anti Estrogen drugs for sale?

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